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KMID : 1137820060270020053
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의공학회지
2006 Volume.27 No. 2 p.53 ~ p.58
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[ $T_2$ ]-relaxation Time Measurement of ex vivo $^1H$ MR Metabolite Peaks for Evaluation of Human Stomach Cancer
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Mun Chi-Woong
Choi Ki-Sueng
Shin Oon-Jae
Yang Young-Ill
Chang Hee-Kyung
Hu Xiaoping
Eun Chung-Ki
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Abstract
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In this study, transverse relaxation time (T2) measurement and the evaluation of the characteristics of the spectral peak related to stomach tissue metabolites were performed using ex vivo proton magnetic resonance spectroscopic imaging (MRSI) at 1.5-T MRI/S instruments. Thirty-two gastric tissues resected from 12 patients during gastric cancer surgery, of which 19 were normal tissue and 13 were cancerous tissue, were used to measure the $T_2$ of the magnetic resonance spectroscopy (MRS) peaks. The volume of interest data results from the MRSI measurements were extracted from the proper muscle (MUS) layer and the composite mucosa/submucosa (MC/SMC) layer and were statistically analyzed. MR spectra were acquired using the chemical shift imaging (CSI) point resolved spectroscopy (CSI-PRESS) technique with the parameters of pulse repetition time (TR) and echo times (TE) TR/(TE1,TE2)=1500 msec/(35 msec, 144 msec), matrix $size=24{\times}24$, NA=1, and voxel $size=2.2{\times}2.2{\times}4mm^3$. In conclusion, the measured $T_2$ of the metabolite peaks, such as choline (3.21ppm) and lipid (1.33ppm), were significantly decreased (p<0.01 and p<0.05, respectively) in the cancerous stomach tissue
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KEYWORD
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magnetic resonance spectroscopy (MRS), magnetic resonance spectroscopic imaging (MRSI, chemical shift imaging: CSI), stomach tissue, cancer, $T_2$-relaxation time
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